Important Safety Facts
  • CREON may increase your chance of having a rare bowel disorder called fibrosing colonopathy. This condition is serious and may require surgery. The risk of having this condition may be reduced by following the dosing instructions that your doctor gave you.
  • The most common side effects include: increased (hyperglycemia) or decreased (hypoglycemia) blood sugars, pain in your stomach area (abdominal area), frequent or abnormal bowel movements, gas, vomiting, dizziness or sore throat and cough.
  • CREON may increase blood uric acid levels. This may cause worsening of swollen, painful joints (gout).
  • CREON and other pancreatic enzyme products are made from the pancreas of pigs, the same pigs people eat as pork. These pigs may carry viruses. Although it has never been reported, it may be possible for a person to get a viral infection from taking pancreatic enzyme products that come from pigs.

Reference: CREON [package insert].

Click to view full Prescribing Information, including Medication Guide.

Before Starting

Tell your doctor if you:

  • are allergic to pork (pig) products
  • have a history of intestinal blockage of your intestines, or scarring or thickening of your bowel wall (fibrosing colonopathy)
  • have gout, kidney disease, or high blood uric acid (hyperuricemia)
  • have trouble swallowing capsules
  • have any other medical condition
  • are pregnant or plan to become pregnant. It is not known if CREON will harm your unborn baby.
  • are breast-feeding or plan to breast-feed. It is not known if CREON passes into your breast milk.

Tell your doctor about all your medical conditions and about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Reference: CREON [package insert].

Click to view full Prescribing Information, including Medication Guide.

Side Effects

Tell your doctor right away if you have any unusual or severe stomach (abdominal) pain; bloating; trouble passing stool; nausea; vomiting; diarrhea; worsening of painful, swollen joints (gout); or allergic reactions including trouble breathing, skin rashes, or swollen lips.

Tell your healthcare provider if you have any symptom or side effect that bothers you or that does not go away.

Reference: CREON [package insert].

Click to view full Prescribing Information, including Medication Guide.

Uses

CREON is a prescription medicine used to treat people who cannot digest food normally because their pancreas does not make enough enzymes due to cystic fibrosis, swelling of the pancreas that lasts a long time (chronic pancreatitis), removal of some or all of the pancreas (pancreatectomy), or other conditions.

Reference: CREON [package insert].

Click to view full Prescribing Information, including Medication Guide.

How to Take
  • Take CREON exactly as your doctor tells you. Do not take more or less CREON than directed by your doctor.
  • Always take CREON with a meal or snack and enough liquid to swallow CREON completely.
  • Do not crush or chew CREON capsules or its contents, and do not hold the capsule or capsule contents in your mouth. Crushing, chewing or holding the CREON capsules in your mouth may cause irritation in your mouth or change the way CREON works in your body. Talk to your doctor or consult the CREON Medication Guide for how to take CREON if you have trouble swallowing capsules.
  • If you forget to take CREON, call your doctor or wait until your next meal and take your usual number of capsules. Take your next dose at your usual time. Do not make up for missed doses.
  • Your doctor may change your dose based on the amount of fatty foods you eat or based on your weight.
  • You should not switch CREON with any other pancreatic enzyme product without first talking to your doctor.

Reference: CREON [package insert].

Click to view full Prescribing Information, including Medication Guide.

Useful Resources

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088 (1-800-332-1088).

If you cannot afford your medication, contact: www.pparx.org or call the toll free phone number (1-888-4PPA-NOW) (1-888-477-2669) for assistance.

Reference: CREON [package insert].

Click to view full Prescribing Information, including Medication Guide.