CREON Dosing for
Children and Adults

Use the CREON dosing guide to determine the appropriate per-meal dosing range

Remember, the CREON dosage you prescribe should be individualized and adjusted based on clinical symptoms, the degree of steatorrhea present, and the fat content of the diet. Dosing of pancreatic enzymes is based on the guidelines established by the Cystic Fibrosis Foundation.1

Usually, half of the prescribed CREON dose for an individualized full meal should be given with each snack.

CREON
Per-meal Dosing Guide

CREON is indicated for the treatment of exocrine pancreatic insufficiency due to cystic fibrosis, chronic pancreatitis, pancreatectomy, or other conditions.

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    Rx Script Example

    ePrescribing Reminder

    Rx Script Example

    CREON (pancrelipase)

    Lipase Units/120 mL

    of formula or per breast-feeding

    30-day total:

    To calculate dispense quantity for 30 days, multiply the max number of feedings given per day x 30 days.

    This is intended for informational use only and shows the minimum appropriate recommended dosing for the patient criteria specified. The total daily dose should not exceed 10,000 lipase units/kg body weight/day unless clinically indicated. CREON dosage should be individualized and adjusted based on the clinical symptoms, degree of steatorrhea present, and the fat content of the diet.

    ePrescribing Reminder

    When using e-prescribing systems, please make sure to specify the number of capsules that should be taken per meal and per snack in the notes area.

    Example notes:

     Lipase Units/120 mL of formula or per breast-feeding.

    To calculate dispense quantity for 30 days, multiply the max number of feedings given per day x 30 days.

    Email Recommended Dose

     

    Perform the CREON dosing check to help recognize when a dose adjustment is needed1

    For appropriate weight-based dosing,
    perform the CREON Dosing Check*:

    *The Cystic Fibrosis Foundation (CFF) Guidelines also provide a dietary fat-based maximum lipase dose of less than 4,000 lipase units per g of fat ingested per day.

    CREON dosing and administration considerations

    • CREON should always be taken with food. CREON should not be crushed or chewed.
    • Usually, half of the prescribed CREON dose for an individualized full meal should be given with each snack.
    • Total daily dose should not exceed 10,000 lipase units/kg body weight/day unless clinically indicated.
    • Fibrosing colonopathy has been reported in patients with cystic fibrosis taking high-dose pancreatic enzyme replacement therapy.

    Instructions for patients who have a hard time
    swallowing capsules

    If your patients have problems swallowing CREON capsules, you can guide them with the following steps:

    Hold CREON® (pancrelipase) capsules upright so you can read the word CREON on the capsule

    Hold the capsule upright so that you can read the word CREON on the capsule.

    Carefully twist off the top portion of the CREON capsule over the food  you plan to eat

    Carefully twist off the top portion of the capsule over the food you plan to eat.

    Sprinkle the contents on a small amount of room temperature acidic food such as applesauce. Ask your doctor about other foods you can mix with CREON. Do not crush the contents of the capsule

    Sprinkle the contents of the capsule on a small amount of room temperature acidic food such as applesauce. Ask your doctor about other foods you can mix with CREON. Do not crush the contents of the capsules.

    Swallow the CREON-soft food mixture right away without chewing and drink enough water or juice to make sure the contents are swallowed completely. Do not store CREON that is mixed with food

    Swallow the CREON-soft food mixture right away without chewing and drink enough water or juice to make sure the contents of the capsules are swallowed completely. Do not store CREON that is mixed with food.

    Instructions for patients who have a hard time
    swallowing capsules

    If your patients have problems swallowing CREON capsules, you can guide them with the following steps:

    Hold CREON® (pancrelipase) capsules upright so you can read the word CREON on the capsule

    Hold the capsule upright so that you can read the word CREON on the capsule.

    Carefully twist the CREON capsule to open it

    Carefully twist off the top portion of the capsule over the food you plan to eat.

    Sprinkle the contents on a small amount of room temperature acidic food such as applesauce

    Sprinkle the contents of the capsule on a small amount of room temperature acidic food such as applesauce. Ask your doctor about other foods you can mix with CREON. Do not crush the contents of the capsules.

    Swallow the CREON-soft food mixture right away without chewing and drink enough water or juice to make sure the contents are swallowed completely

    Swallow the CREON-soft food mixture right away without chewing and drink enough water or juice to make sure the contents of the capsules are swallowed completely. Do not store CREON that is mixed with food.

    Sprinkling instructions

    Hold CREON® (pancrelipase) capsules upright so you can read the word CREON on the capsule

    Hold the capsule upright so that you can read the word CREON on the capsule.

    Carefully twist off the top portion of the capsule

    Carefully twist off the top portion of the capsule.

    Sprinkle the contents of the capsule directly into the infant’s mouth, or mix the contents in a small amount of room temperature acidic soft food such as applesauce or jarred baby food. Do not mix CREON with formula or bottled breast milk. If you sprinkled CREON on soft food, feed it to the child immediately. Do not store CREON that is mixed with food.

    Sprinkle the contents of the capsule directly into the infant’s mouth, or mix the contents in a small amount of room temperature acidic soft food such as applesauce or jarred baby food.   Do not mix CREON with formula or bottled breast milk. If you sprinkled CREON on soft food, feed it to the child immediately. Do not store CREON that is mixed with food.

    Give the child enough liquid to completely swallow the CREON contents or the CREON and food mixture. Look in the child’s mouth to make sure that all of the medicine has been swallowed. Any medicine left in the mouth may cause irritation

    Give the child enough liquid to completely swallow the CREON contents or the CREON and food mixture. Look in the child’s mouth to make sure that all of the medicine has been swallowed. Any medicine left in the mouth may cause irritation.

    Use the CREON® (pancrelipase) Treatment Tracker to help educate patients about their therapy

    Encourage patients to track treatment and share the results with you

    Download
    Treatment Tracker
    CREON® (pancrelipase) support programs offer nutritional, educational and financial assistance

    CREON patient support programs offer financial, multivitamin, and educational support

    See Patient Support
    Programs
    Request patient starter kits, product samples, and more

    Request patient starter kits, product samples, and more

    Contact a Rep

    Indications and Important
    Safety Information

    Indications1

    CREON® (pancrelipase) Delayed-Release Capsules is a pancrelipase which is a combination of porcine-derived lipases, proteases, and amylases indicated for the treatment of exocrine pancreatic insufficiency due to cystic fibrosis, chronic pancreatitis, pancreatectomy, or other conditions.

    Important Safety Information

    • Fibrosing colonopathy is associated with high-dose use of pancreatic enzyme replacement in the treatment
      of cystic fibrosis patients. Exercise caution when doses of CREON exceed 2,500 lipase units/kg of body weight
      per meal (or greater than 10,000 lipase units/kg of body weight per day).
    • To avoid irritation of oral mucosa, care should be taken to ensure that CREON is not crushed, chewed, or retained in the mouth. CREON should always be taken with food.
    • Porcine-derived pancreatic enzyme products contain purines. Caution should be exercised when prescribing CREON to patients with gout, renal impairment, or hyperuricemia.
    • There is theoretical risk of viral transmission with all pancreatic enzyme products including CREON.
    • Exercise caution when administering pancrelipase to a patient with a known allergy to proteins of porcine origin.
    • Adverse reactions that occurred in at least 2 cystic fibrosis patients (greater than or equal to 4%) receiving CREON were vomiting, dizziness, and cough.
    • Adverse reactions that occurred in at least 1 chronic pancreatitis or pancreatectomy patient (greater than or equal to 4%) receiving CREON were hyperglycemia, hypoglycemia, abdominal pain, abnormal feces, flatulence, frequent bowel movements, and nasopharyngitis.
    • CREON is not interchangeable with any other pancrelipase product.

    Reference: 1. CREON [package insert]. North Chicago, IL: AbbVie Inc.

    1. Reference:
    2. CREON [package insert]. North Chicago, IL: AbbVie Inc.

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