Helping patients get started
with CREON

CREON treatment expectations to discuss with patients


Inform

patients that EPI can be a chronic condition and may require long-term management.2,3


Instruct

patients to take CREON with every meal and snack—with sufficient fluid—and remind them that capsules should not be crushed or chewed.1


Follow up

with patients to discuss symptoms and diet to assess the need for a dose adjustment.1

Schedule follow-up appointments as early as 7 days* after starting patients on CREON1

Follow-up appointments are an important way to assess if your patients are receiving an appropriate dose and taking their CREON correctly. During follow-ups, continue to discuss and evaluate any changes in weight, administration habits, and/or symptoms to determine if your patient’s dose is appropriate and whether a dose adjustment is necessary.


Encourage patients to use the Treatment Tracker to record their symptoms, dietary habits, and dosing/administration routines and share it with you at their next follow-up appointment.

CREON dosage should be individualized based on1:

Clinical symptoms

Degree of steatorrhea present

Dietary fat content

Safety and dosing considerations

  • Fibrosing colonopathy has been reported in patients with cystic fibrosis taking high-dose pancreatic enzyme replacement therapy.
  • Total daily dose should not exceed 10,000 lipase units/kg body weight/day unless clinically indicated.
  • CREON is not interchangeable with other pancrelipase products.
  • CREON should be initiated at the lowest recommended dose based on the patient's weight.
  • CREON should always be taken with food. 
  • CREON should not be crushed or chewed.
  • The dosage of CREON should be individualized based on degree of steatorrhea present and fat content of the diet.
  • Usually, half of the prescribed CREON dose for an individualized full meal should be given with each snack.

Review CREON dosing and administration guidelines for patients with EPI due to:

*In clinical studies, improvement in fat absorption after treatment with CREON was assessed as early as 5-7 days.
The CFF Guidelines also provide a dietary fat-based maximum lipase dose of less than 4,000 units per g of fat ingested per day.

EPI = exocrine pancreatic insufficiency.