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Dosing &
Administration

Getting started with CREON 36K

36K capsules can be an appropriate strength for many patients¹

one CREON 36K lipase unit capsule — Usually, half of the prescribed CREON dose for an individualized full meal should be given with each snack.¹

This chart is intended to be a guide. CREON capsules represent nearest capsule count within recommended dosing range.

Patients weighing <110 lb may require a lower lipase unit starting dose. Patients weighing >315 lb may require a higher lipase unit starting dose.

The CREON dosage you prescribe should be initiated at the lowest recommended dose based on the patient’s weight and individualized based on clinical symptoms, the degree of steatorrhea present, and the fat content of the diet.¹ Dosing of pancreatic enzymes is based on the guidelines established by the Cystic Fibrosis Foundation (CFF). The CFF guidelines also provide dosing based on fat ingested per day.¹

**CREON 36,000 may not be appropriate for all patients. CREON is available in 3,000, 6,000, 12,000, and 24,000 lipase unit capsules.¹**

two CREON 36K lipase unit capsules — Usually, half of the prescribed CREON dose for an individualized full meal should be given with each snack.¹

This chart is intended to be a guide. CREON capsules represent nearest capsule count within recommended dosing range.

Patients weighing <110 lb may require a lower lipase unit starting dose. Patients weighing >315 lb may require a higher lipase unit starting dose.

The CREON dosage you prescribe should be initiated at the lowest recommended dose based on the patient’s weight and individualized based on clinical symptoms, the degree of steatorrhea present, and the fat content of the diet.¹ Dosing of pancreatic enzymes is based on the guidelines established by the Cystic Fibrosis Foundation (CFF). The CFF guidelines also provide dosing based on fat ingested per day.¹

**CREON 36,000 may not be appropriate for all patients. CREON is available in 3,000, 6,000, 12,000, and 24,000 lipase unit capsules.¹**

Prescribe for both meals
and snacks

When writing prescriptions (on paper or e-prescribing systems),
make sure to specify the number of capsules that should be
taken per meal and per snack.¹ Usually half of the prescribed
CREON dose for an individualized full meal should be given with each snack.¹

CREON should be taken during every meal and snack¹

sample dinner and snack to take CREON with

Meals and snacks are for illustrative purposes only.

This is a sample CREON script for a patient who weighs 160 lbs. It includes fields for the patient’s name, patient’s address, date and physician signature. It says CREON (pancrelipase) 36,000 Lipase Units. 2 caps po during each meal. 1 caps po during each snack. 30-day total: 240 capsules. Note: Take during every meal and snack. — Sample script for a patient who weighs 160 lb.¹

See additional dosing and administration guidelines for patients
with EPI due to:

Cystic Fibrosis

Chronic Pancreatitis
or Pancreatectomy

Other Conditions

Indications and Important
Safety Information

Indications¹

CREON^® (pancrelipase) Delayed-Release Capsules is a pancrelipase which is a combination of porcine-derived lipases, proteases, and amylases indicated for the treatment of exocrine pancreatic insufficiency due to cystic fibrosis, chronic pancreatitis, pancreatectomy, or other conditions.

Important Safety Information

Fibrosing colonopathy is associated with high-dose use of pancreatic enzyme replacement in the treatment
of cystic fibrosis patients. Exercise caution when doses of CREON exceed 2,500 lipase units/kg of body weight
per meal (or greater than 10,000 lipase units/kg of body weight per day).
To avoid irritation of oral mucosa, care should be taken to ensure that CREON is not crushed, chewed, or retained in the mouth. CREON should always be taken with food.
Porcine-derived pancreatic enzyme products contain purines. Caution should be exercised when prescribing CREON to patients with gout, renal impairment, or hyperuricemia.
There is theoretical risk of viral transmission with all pancreatic enzyme products including CREON.
Exercise caution when administering pancrelipase to a patient with a known allergy to proteins of porcine origin.
Adverse reactions that occurred in at least 2 cystic fibrosis patients (greater than or equal to 4%) receiving CREON were vomiting, dizziness, and cough.
Adverse reactions that occurred in at least 1 chronic pancreatitis or pancreatectomy patient (greater than or equal to 4%) receiving CREON were hyperglycemia, hypoglycemia, abdominal pain, abnormal feces, flatulence, frequent bowel movements, and nasopharyngitis.
CREON is not interchangeable with any other pancrelipase product.

Dosing & Administration

Getting started with CREON 36K

36K capsules can be an appropriate strength for many patients1

Prescribe for both meals and snacks

CREON should be taken during every meal and snack1

See additional dosing and administration guidelines for patients with EPI due to:

Indications and Important Safety Information

Indications1