CREON Dosing Guide

Determine your patient’s dose

The dosing guide calculates an appropriate dose or dosing range for each patient based on guidelines established by the Cystic Fibrosis Foundation (CFF).1

CREON
Per-meal Dosing Guide

CREON is indicated for the treatment of Exocrine Pancreatic Insufficiency due to cystic fibrosis, chronic pancreatitis, pancreatectomy, or other conditions.

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    Rx Script Example

    ePrescribing Reminder

    Rx Script Example

    CREON (pancrelipase)

    Lipase Units/120 mL

    of formula or per breastfeeding

    30-day total:

    To calculate dispense quantity for 30 days, multiply the max number of feedings given per day x 30 days.

    This is intended for informational use only and shows the minimum appropriate recommended dosing for the patient criteria specified. The total daily dose should not exceed 10,000 lipase units/kg body weight/day unless clinically indicated. CREON dosage should be individualized and adjusted based on the clinical symptoms, degree of steatorrhea present, and the fat content of the diet.

    ePrescribing Reminder

    When using e-prescribing systems, please make sure to specify the number of capsules that should be taken per meal and per snack in the notes area.

    Example notes:

     Lipase Units/120 mL of formula or per breastfeeding.

    To calculate dispense quantity for 30 days, multiply the max number of feedings given per day x 30 days.

    CREON should be taken during every meal and snack1

    Plate of chicken, potato, and greens A bowl of nuts

    Meals and snacks are for illustrative purposes only.

    Safety and dosing considerations

    • CREON should be initiated at the lowest recommended dose based on the patient’s weight.
    • CREON should always be taken with food. CREON should not be crushed or chewed.
    • Usually, half of the prescribed CREON dose for an individualized full meal should be given with each snack.
    • Total daily dose should not exceed 10,000 lipase units/kg body weight/day unless clinically indicated.
    • Fibrosing colonopathy has been reported in patients with cystic fibrosis taking high-dose pancreatic enzyme replacement therapy.

    The CFF Guidelines also provide a dietary fat-based maximum lipase dose of less than 4,000 units per g of fat ingested per day.

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