Remember to take the following into account when determining an appropriate PERT dosage and writing a prescription. It’s important to discuss these dosing reminders with patients so that they understand why their specific dose was chosen and when to take it.
When dosing PERTs, consider patient weight and adjust dose based on clinical symptoms, steatorrhea, and dietary fat content.12,13
EPI = exocrine pancreatic insufficiency.
CREON® (pancrelipase) Delayed-Release Capsules is a pancrelipase which is a combination of porcine-derived lipases, proteases, and amylases indicated for the treatment of exocrine pancreatic insufficiency due to cystic fibrosis, chronic pancreatitis, pancreatectomy, or other conditions.
Please see Full Prescribing Information.
US-CREO-220154
References: 1. CREON [package insert]. North Chicago, IL: AbbVie Inc. 2. Fieker A, Philpott J, Armand M. Enzyme replacement therapy for pancreatic insufficiency: present and future. Clin Exp Gastroenterol. 2011;4:55-73. 3. Smith RC, Smith SF, Wilson J, et al; Working Party of the Australasian Pancreatic Club. Summary and recommendations from the Australasian guidelines for the management of pancreatic exocrine insufficiency. Pancreatology. 2016;16(2):164-180. doi:10.1016/j.pan.2015.12.006 4. Pancreatic enzymes. Pancreatic Action Network. Accessed January 11, 2023. https://www.pancan.org/facing-pancreatic-cancer/living-with-pancreatic-cancer/diet-and-nutrition/pancreatic-enzymes/ 5. Domínguez-Muñoz JE. Pancreatic enzyme therapy for pancreatic exocrine insufficiency. Curr Gastroenterol Rep. 2007;9(2):116-122. 6. Vitamin E. MedlinePlus website. Updated September 27, 2021. Accessed May 24, 2022. https://medlineplus.gov/vitamine.html 7. Vitamin D. MedlinePlus website. Updated September 23, 2021. Accessed May 24, 2022. https://medlineplus.gov/vitamind.html 8. Vitamin K. MedlinePlus website. Updated September 27, 2021. Accessed May 24, 2022. https://medlineplus.gov/vitamink.html 9. Vitamin E. National Institutes of Health website. Updated March 26, 2021. Accessed May 24, 2022. https://ods.od.nih.gov/factsheets/VitaminE-HealthProfessional/ 10. Vitamin A. MedlinePlus website. Updated September 23, 2022. Accessed May 24, 2022. https://medlineplus.gov/vitamina.html 11. Lindkvist B. Diagnosis and treatment of pancreatic exocrine insufficiency. World J Gastroenterol. 2013;19(42):7258-7266. 12. Borowitz DS, Grand RJ, Durie PR. Use of pancreatic enzyme supplements for patients with cystic fibrosis in the context of fibrosing colonopathy. Consensus Committee. J Pediatr. 1995;127(5):681-684. 13. Windsor JA. Pancreatic enzyme replacement therapy in chronic pancreatitis: a long way to go. Gut. 2017;66(8):1354-1355.
