Exocrine Pancreatic Insufficiency (EPI) Management

Pancreatic enzyme replacement therapies (PERTs) are the standard of care for EPI management2

PERTs replace 3 types of enzymes that are not properly secreted in patients with EPI2

CREON® (pancrelipase) replaces pancreatic enzymes such as lipase

Lipase

CREON® (pancrelipase) replaces pancreatic enzymes such as protease

Protease

CREON® (pancrelipase) replaces pancreatic enzymes such as amylase

Amylase

A comprehensive EPI management plan should include more than pancreatic enzyme replacement therapy3

Pancreatic
enzyme
replacement
therapy (PERT)
Diet and
lifestyle
modifications
Lifestyle modifications,
including a nutritionally well-
balanced diet, abstaining from
alcohol, and smoking cessation
Vitamin
supplements
Vitamin and mineral
supplements, including
fat-soluble vitamins
A, D, E, and K

These fat-soluble vitamins are important for multiple reasons. Vitamins A and E are antioxidants and may protect against free radicals. Vitamin D aids in calcium absorption and subsequent bone growth. Vitamin K is necessary for the clotting of blood.4-7

Understand the impact that EPI can have

Understand the impact that EPI can have

Learn More
Symptoms of EPI are not always evident. Learn to recognize the signs

Symptoms of EPI are not always evident

Recognize the Signs
EPI is largely a clinical diagnosis

EPI is largely a clinical diagnosis*

*Tests can help confirm a diagnosis of EPI.

Get the Details

Indications and Important
Safety Information

Indications1

CREON® (pancrelipase) Delayed-Release Capsules is a pancrelipase which is a combination of porcine-derived lipases, proteases, and amylases indicated for the treatment of exocrine pancreatic insufficiency due to cystic fibrosis, chronic pancreatitis, pancreatectomy, or other conditions.

Important Safety Information

  • Fibrosing colonopathy is associated with high-dose use of pancreatic enzyme replacement in the treatment
    of cystic fibrosis patients. Exercise caution when doses of CREON exceed 2,500 lipase units/kg of body weight
    per meal (or greater than 10,000 lipase units/kg of body weight per day).
  • To avoid irritation of oral mucosa, care should be taken to ensure that CREON is not crushed, chewed, or retained in the mouth. CREON should always be taken with food.
  • Porcine-derived pancreatic enzyme products contain purines. Caution should be exercised when prescribing CREON to patients with gout, renal impairment, or hyperuricemia.
  • There is theoretical risk of viral transmission with all pancreatic enzyme products including CREON.
  • Exercise caution when administering pancrelipase to a patient with a known allergy to proteins of porcine origin.
  • Adverse reactions that occurred in at least 2 cystic fibrosis patients (greater than or equal to 4%) receiving CREON were vomiting, dizziness, and cough.
  • Adverse reactions that occurred in at least 1 chronic pancreatitis or pancreatectomy patient (greater than or equal to 4%) receiving CREON were hyperglycemia, hypoglycemia, abdominal pain, abnormal feces, flatulence, frequent bowel movements, and nasopharyngitis.
  • CREON is not interchangeable with any other pancrelipase product.

Reference: 1. CREON [package insert]. North Chicago, IL: AbbVie Inc.

  1. References:
  2. CREON [package insert]. North Chicago, IL: AbbVie Inc.
  3. Fieker A, Philpott J, Armand M. Enzyme replacement therapy for pancreatic insufficiency: present and future. Clin Exp Gastroenterol. 2011;4:55-73.
  4. Domínguez-Muñoz JE. Pancreatic enzyme therapy for pancreatic exocrine insufficiency. Curr Gastroenterol Rep. 2007;9(2):116-122.
  5. Vitamin A. MedlinePlus website. http://www.nlm.nih.gov​/medlineplus​/ency​/article​/002400.htm. Updated July 28, 2015. Accessed August 11, 2015.
  6. Vitamin E. MedlinePlus website. http://www.nlm.nih.gov​/medlineplus​/ency​/article​/002406.htm. Updated July 28, 2015. Accessed August 11, 2015.
  7. Vitamin D. MedlinePlus website. http://www.nlm.nih.gov​/medlineplus​/vitamind.html. Updated August 4, 2015. Accessed August 11, 2015.
  8. Vitamin K. MedlinePlus website. http://www.nlm.nih.gov​/medlineplus​/vitamink.html. Updated July 7, 2015. Accessed August 11, 2015.

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