Mechanism of Action

See how CREON works

CREON is a pancrelipase that replaces enzymes that are normally secreted by the pancreas. CREON is
formulated to deliver enzymes to the duodenum where the pH is the most conducive to enzymatic activity.
Instruct your patients to always take CREON with food. CREON should not be crushed or chewed.1

CREON and food need to be taken at the same time.

Along with food, the CREON capsules enter the stomach.

Capsule releases enteric-coated spheres sized between 0.7 and 1.6 mm in diameter.

Enteric coating allows the spheres to travel beyond the low pH of the stomach through the pylorus, releasing enzymes into the small intestines at a pH ≥5.5.

CREON enteric-coated spheres dissolve in the small intestine, releasing pancreatic enzymes to mix with food.

In the small intestine, these enzymes work to break down fats, proteins, and carbohydrates in food.

Use the dosing calculator to help determine the proper dosage of CREON® (pancrelipase)

Determine an appropriate per-meal dose for your patients

Use Dosing Guide
CREON® (pancrelipase) is offered in different dosages, depending on a variety of factors

CREON offers a wide range of dosing strengths

See Dosing Strengths
CREON® (pancrelipase) support programs offer nutritional, educational and financial assistance

CREON patient support programs offer financial, multivitamin, and educational support

See Patient Support

Indications and Important
Safety Information


CREON® (pancrelipase) Delayed-Release Capsules is a pancrelipase which is a combination of porcine-derived lipases, proteases, and amylases indicated for the treatment of exocrine pancreatic insufficiency due to cystic fibrosis, chronic pancreatitis, pancreatectomy, or other conditions.

Important Safety Information

  • Fibrosing colonopathy is associated with high-dose use of pancreatic enzyme replacement in the treatment
    of cystic fibrosis patients. Exercise caution when doses of CREON exceed 2,500 lipase units/kg of body weight
    per meal (or greater than 10,000 lipase units/kg of body weight per day).
  • To avoid irritation of oral mucosa, care should be taken to ensure that CREON is not crushed, chewed, or retained in the mouth. CREON should always be taken with food.
  • Porcine-derived pancreatic enzyme products contain purines. Caution should be exercised when prescribing CREON to patients with gout, renal impairment, or hyperuricemia.
  • There is theoretical risk of viral transmission with all pancreatic enzyme products including CREON.
  • Exercise caution when administering pancrelipase to a patient with a known allergy to proteins of porcine origin.
  • Adverse reactions that occurred in at least 2 cystic fibrosis patients (greater than or equal to 4%) receiving CREON were vomiting, dizziness, and cough.
  • Adverse reactions that occurred in at least 1 chronic pancreatitis or pancreatectomy patient (greater than or equal to 4%) receiving CREON were hyperglycemia, hypoglycemia, abdominal pain, abnormal feces, flatulence, frequent bowel movements, and nasopharyngitis.
  • CREON is not interchangeable with any other pancrelipase product.

Reference: 1. CREON [package insert]. North Chicago, IL: AbbVie Inc.

  1. Reference:
  2. CREON [package insert]. North Chicago, IL: AbbVie Inc.

back to top #tbd