CREON Bite-sized
Education Series

How CREON works

CREON and food need to be taken together so they travel down the digestive tract and reach the small intestine, where CREON works to break down the food into nutrients.

View transcript

Narrator1:

CREON, pancrelipase, is a prescription medicine that works by replacing the pancreatic enzymes that are missing in people who have EPI...

....due to cystic fibrosis, chronic pancreatitis (which is the swelling of the pancreas that lasts a long time), pancreatectomy (which is the removal of some or all of the pancreas), or other conditions.

CREON needs to be taken with every meal and snack, and there’s a good reason why.

Your pancreas PRODUCES enzymes every time you eat...

...so CREON is used to REPLACE those enzymes every time you eat.

It’s important to always take CREON with a meal or snack and enough liquid to swallow the capsules completely.

Also, be sure not to chew or crush CREON capsules.

In order to work, CREON needs to get to the right location in the body to do its job...

...and it needs to travel down the digestive tract with your food.

Timing is key. CREON and food need to get on board together...

...so that they reach their destination together.

CREON has a special coating to make sure it reaches the starting point of your small intestine (which is called your duodenum).

Your duodenum is where CREON releases enzymes to break down the fats, proteins, and carbohydrates in your food...

...so that they can be absorbed and used by your body.

So remember, if you have EPI, CREON can help break down your food so that nutrients can get to their final destination.

Uses

CREON is a prescription medicine used to treat people who cannot digest food normally because their pancreas does not make enough enzymes due to cystic fibrosis, chronic pancreatitis (which is the swelling of the pancreas that lasts a long time), pancreatectomy (which is the removal of some or all of the pancreas), or other conditions.

Important Safety Information

  • CREON may increase your chance of having a rare bowel disorder called fibrosing colonopathy. The risk of having this condition may be reduced by following the dosing instructions that your doctor gave you.
  • Do not crush or chew CREON capsules or its contents, and do not hold the capsule or capsule contents in your mouth. Crushing, chewing, or holding the CREON capsules in your mouth may cause irritation in your mouth. Talk to your doctor or consult the CREON Medication Guide for how to take CREON if you have trouble swallowing capsules. Always take CREON with a meal or snack and enough liquid to swallow CREON completely. Take CREON exactly as your doctor tells you.
  • Tell your doctor right away if you have unusual or severe: stomach or abdominal pain, bloating, trouble passing stool, nausea, vomiting, diarrhea, worsening of painful, swollen joints (gout), or allergic reactions including trouble with breathing, skin rashes, or swollen lips.
  • The most common side effects include: increased or decreased blood sugars, pain in your stomach area, frequent or abnormal bowel movements, gas, vomiting, dizziness, or sore throat and cough.
  • CREON and other pancreatic enzyme products are made from the pancreas of pigs, the same pigs people eat as pork. These pigs may carry viruses. Although it has never been reported, it may be possible for a person to get a viral infection from taking pancreatic enzyme products that come from pigs.

Refer to the CREON Medication Guide and full Prescribing Information every time you refill your prescription because information may change. Tell your healthcare provider if you have any symptom or side effect that bothers you or does not go away.

You are encouraged to report negative adverse effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you cannot afford your medication, contact www.pparx.org.

Please see the full Prescribing Information, including Medication Guide, provided on this website and discuss it with your doctor.

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Video Transcript

Narrator1:

CREON, pancrelipase, is a prescription medicine that works by replacing the pancreatic enzymes that are missing in people who have EPI...

....due to cystic fibrosis, chronic pancreatitis (which is the swelling of the pancreas that lasts a long time), pancreatectomy (which is the removal of some or all of the pancreas), or other conditions.

CREON needs to be taken with every meal and snack, and there’s a good reason why.

Your pancreas PRODUCES enzymes every time you eat...

...so CREON is used to REPLACE those enzymes every time you eat.

It’s important to always take CREON with a meal or snack and enough liquid to swallow the capsules completely.

Also, be sure not to chew or crush CREON capsules.

In order to work, CREON needs to get to the right location in the body to do its job...

...and it needs to travel down the digestive tract with your food.

Timing is key. CREON and food need to get on board together...

...so that they reach their destination together.

CREON has a special coating to make sure it reaches the starting point of your small intestine (which is called your duodenum).

Your duodenum is where CREON releases enzymes to break down the fats, proteins, and carbohydrates in your food...

...so that they can be absorbed and used by your body.

So remember, if you have EPI, CREON can help break down your food so that nutrients can get to their final destination.

Uses

CREON is a prescription medicine used to treat people who cannot digest food normally because their pancreas does not make enough enzymes due to cystic fibrosis, chronic pancreatitis (which is the swelling of the pancreas that lasts a long time), pancreatectomy (which is the removal of some or all of the pancreas), or other conditions.

Important Safety Information

  • CREON may increase your chance of having a rare bowel disorder called fibrosing colonopathy. The risk of having this condition may be reduced by following the dosing instructions that your doctor gave you.
  • Do not crush or chew CREON capsules or its contents, and do not hold the capsule or capsule contents in your mouth. Crushing, chewing, or holding the CREON capsules in your mouth may cause irritation in your mouth. Talk to your doctor or consult the CREON Medication Guide for how to take CREON if you have trouble swallowing capsules. Always take CREON with a meal or snack and enough liquid to swallow CREON completely. Take CREON exactly as your doctor tells you.
  • Tell your doctor right away if you have unusual or severe: stomach or abdominal pain, bloating, trouble passing stool, nausea, vomiting, diarrhea, worsening of painful, swollen joints (gout), or allergic reactions including trouble with breathing, skin rashes, or swollen lips.
  • The most common side effects include: increased or decreased blood sugars, pain in your stomach area, frequent or abnormal bowel movements, gas, vomiting, dizziness, or sore throat and cough.
  • CREON and other pancreatic enzyme products are made from the pancreas of pigs, the same pigs people eat as pork. These pigs may carry viruses. Although it has never been reported, it may be possible for a person to get a viral infection from taking pancreatic enzyme products that come from pigs.

Refer to the CREON Medication Guide and full Prescribing Information every time you refill your prescription because information may change. Tell your healthcare provider if you have any symptom or side effect that bothers you or does not go away.

You are encouraged to report negative adverse effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you cannot afford your medication, contact www.pparx.org.

Please see the full Prescribing Information, including Medication Guide, provided on this website and discuss it with your doctor.

Uses and Important Safety Information

Uses1

CREON is a prescription medicine used to treat people who cannot digest food normally because their pancreas does not make enough enzymes due to cystic fibrosis, swelling of the pancreas that lasts a long time (chronic pancreatitis), removal of some or all of the pancreas (pancreatectomy), or other conditions.

Important Safety Information

  • CREON may increase your chance of having a rare bowel disorder called fibrosing colonopathy. The risk of having this condition may be reduced by following the dosing instructions that your doctor gave you.
  • Do not crush or chew CREON capsules or its contents, and do not hold the capsule or capsule contents in your mouth. Crushing, chewing, or holding the CREON capsules in your mouth may cause irritation in your mouth. Talk to your doctor or consult the CREON Medication Guide for how to take CREON if you have trouble swallowing capsules. Always take CREON with a meal or snack and enough liquid to swallow CREON completely. Take CREON exactly as your doctor tells you.
  • Tell your doctor right away if you have unusual or severe: stomach (abdominal) pain, bloating, trouble passing stool, nausea, vomiting, diarrhea, worsening of painful, swollen joints (gout), or allergic reactions including trouble with breathing, skin rashes, or swollen lips.
  • The most common side effects include: increased (hyperglycemia) or decreased (hypoglycemia) blood sugars, pain in your stomach area (abdominal area), frequent or abnormal bowel movements, gas, vomiting, dizziness, or sore throat and cough.
  • CREON and other pancreatic enzyme products are made from the pancreas of pigs, the same pigs people eat as pork. These pigs may carry viruses. Although it has never been reported, it may be possible for a person to get a viral infection from taking pancreatic enzyme products that come from pigs.

Refer to the CREON Medication Guide and Full Prescribing Information every time you refill your prescription because information may change. Tell your healthcare provider if you have any symptom or side effect that bothers you or that does not go away.

You are encouraged to report negative adverse effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you cannot afford your medication, contact www.pparx.org.

Reference: 1. CREON [package insert]. North Chicago, IL: AbbVie Inc.

  1. References:
  2. CREON [package insert]. North Chicago, IL: AbbVie Inc.
  3. Fieker A, Philpott J, Armand M. Enzyme replacement therapy for pancreatic insufficiency: present and future. Clin Exp Gastroenterol. 2011;4:55-73.
  4. Ferrone M, Raimondo M, Scolapio JS. Pancreatic enzyme pharmacotherapy. Pharmacotherapy. 2007;27(6):910-920.

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