Dosing & Administration for patients with EPI due to chronic pancreatitis or pancreatectomy

Getting started with CREON 36K

Specific dosing for patients with EPI due to chronic pancreatitis (CP) or pancreatectomy

An example with CREON 36K:

CREON 36K
LIPASE UNIT CAPSULES

two CREON 36K lipase unit capsules
2 during meals
one CREON 36K lipase unit capsule
1 during snacks

Capsules shown are not actual size and do not represent the exact color shade.

CREON 36,000 may not be appropriate for all patients. CREON is available in 3,000, 6,000, 12,000, and 24,000 lipase unit capsules.

  • CP/Pancreatectomy Study: Patients received either placebo or 72,000 units of lipase per main meal (3 main meals) and 36,000 units per snack (2 snacks) while consuming ≥100 g of fat per day.1,2
  • Usually, half of the prescribed CREON dose for an individualized full meal should be given with each snack.1
  • Adverse reactions that occurred in at least 1 chronic pancreatitis or pancreatectomy patient (≥4%) receiving CREON were hyperglycemia, hypoglycemia, abdominal pain, abnormal feces, flatulence, frequent bowel movements, and nasopharyngitis.1

CREON should be taken during every meal and snack1

sample chicken, potato and salad dinner and pecan snack to take CREON with sample chicken, potato and salad dinner and pecan snack to take CREON with

Meals and snacks are for illustrative purposes only.

When titrating, prescribe a dose within the recommended range based on patient weight1*

110 lb

49.9 kg

MINIMUM per-meal dose

one CREON 36K lipase unit capsule

36,000 lipase units

MAXIMUM per-meal dose

one CREON 36K lipase unit capsule one CREON 36K lipase unit capsule one CREON 36K lipase unit capsule

108,000 lipase units

130 lb

59.0 kg

MINIMUM per-meal dose

one CREON 36K lipase unit capsule

36,000 lipase units

MAXIMUM per-meal dose

one CREON 36K lipase unit capsule one CREON 36K lipase unit capsule one CREON 36K lipase unit capsule one CREON 36K lipase unit capsule

144,000 lipase units

160 lb

72.6 kg

MINIMUM per-meal dose

one CREON 36K lipase unit capsule one CREON 36K lipase unit capsule

72,000 lipase units

MAXIMUM per-meal dose

one CREON 36K lipase unit capsule one CREON 36K lipase unit capsule one CREON 36K lipase unit capsule one CREON 36K lipase unit capsule one CREON 36K lipase unit capsule

180,000 lipase units

200 lb

90.7 kg

MINIMUM per-meal dose

one CREON 36K lipase unit capsule one CREON 36K lipase unit capsule

72,000 lipase units

MAXIMUM per-meal dose

one CREON 36K lipase unit capsule one CREON 36K lipase unit capsule one CREON 36K lipase unit capsule one CREON 36K lipase unit capsule one CREON 36K lipase unit capsule one CREON 36K lipase unit capsule

216,000 lipase units

230 lb

104.3 kg

MINIMUM per-meal dose

one CREON 36K lipase unit capsule one CREON 36K lipase unit capsule

72,000 lipase units

MAXIMUM per-meal dose

one CREON 36K lipase unit capsule one CREON 36K lipase unit capsule one CREON 36K lipase unit capsule one CREON 36K lipase unit capsule one CREON 36K lipase unit capsule one CREON 36K lipase unit capsule one CREON 36K lipase unit capsule

252,000 lipase units

*Based on guidelines established by the Cystic Fibrosis Foundation (CFF).

This chart is intended to be a guide for the CREON 36,000 lipase unit dosing option. CREON capsules represent nearest capsule count within the recommended dosing range.

Capsules shown are not actual size and do not represent the exact color shade. For illustrative purposes only.

CREON 36,000 may not be appropriate for all patients. CREON is available in 3,000, 6,000, 12,000, and 24,000 lipase unit capsules.1

Dosing and administration considerations

  • CREON should always be taken with food. CREON should not be crushed or chewed.
  • If a CREON dose is missed, the next dose should be taken with the next meal. Doses should not be doubled.
  • Total daily does should not exceed 10,000 lipase units/kg body weight/day unless clinically indicated.

Instructions for patients who have a hard time swallowing capsules

If your patients have problems swallowing CREON capsules, you can guide them with the following steps:

Hold the capsule upright so that you can read the word CREON on the capsule.

Carefully twist off the top portion of the capsule over the food you plan to eat.

Sprinkle the contents of the capsule on a small amount of room temperature acidic food such as applesauce. Ask your doctor about other foods you can mix with CREON. Do not crush the contents of the capsules.

Swallow the CREON soft food mixture right away without chewing and drink enough water or juice to make sure the contents of the capsules are swallowed completely. Do not store CREON that is mixed with food.

Use the CREON® (pancrelipase) Treatment Tracker to help educate patients about their therapy

Encourage patients to track treatment and share the results with you

Download
Treatment Tracker
CREON On Course makes it easy for patients to receive benefits for CREON

Help patients get financial, nutritional, and educational resources

Learn More
Request patient starter kits, product samples, and more

Request patient starter kits, product samples, and more

Contact a Rep

Indications and Important
Safety Information

Indications1

CREON® (pancrelipase) Delayed-Release Capsules is a pancrelipase which is a combination of porcine-derived lipases, proteases, and amylases indicated for the treatment of exocrine pancreatic insufficiency due to cystic fibrosis, chronic pancreatitis, pancreatectomy, or other conditions.

Important Safety Information

  • Fibrosing colonopathy is associated with high-dose use of pancreatic enzyme replacement in the treatment
    of cystic fibrosis patients. Exercise caution when doses of CREON exceed 2,500 lipase units/kg of body weight
    per meal (or greater than 10,000 lipase units/kg of body weight per day).
  • To avoid irritation of oral mucosa, care should be taken to ensure that CREON is not crushed, chewed, or retained in the mouth. CREON should always be taken with food.
  • Porcine-derived pancreatic enzyme products contain purines. Caution should be exercised when prescribing CREON to patients with gout, renal impairment, or hyperuricemia.
  • There is theoretical risk of viral transmission with all pancreatic enzyme products including CREON.
  • Exercise caution when administering pancrelipase to a patient with a known allergy to proteins of porcine origin.
  • Adverse reactions that occurred in at least 2 cystic fibrosis patients (greater than or equal to 4%) receiving CREON were vomiting, dizziness, and cough.
  • Adverse reactions that occurred in at least 1 chronic pancreatitis or pancreatectomy patient (greater than or equal to 4%) receiving CREON were hyperglycemia, hypoglycemia, abdominal pain, abnormal feces, flatulence, frequent bowel movements, and nasopharyngitis.
  • CREON is not interchangeable with any other pancrelipase product.

Reference: 1. CREON [package insert]. North Chicago, IL: AbbVie Inc.

  1. References:
  2. CREON [package insert]. North Chicago, IL: AbbVie Inc.
  3. Whitcomb DC, Lehman GA, Vasileva G, et al. Pancrelipase delayed-release capsules (CREON) for exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery: a double-blind randomized trial. Am J Gastroenterol. 2010;105(10):2‌276-‌2286.

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