CREON On Course

Support for people with EPI due to chronic pancreatitis, pancreatectomy, or other
conditions that are not cystic fibrosis

CREON® (pancrelipase) support materials

Pancreatic enzyme replacement therapy (PERT) is just one part of treating exocrine pancreatic insufficiency (EPI). Your doctor may recommend that you take vitamin supplements—including vitamins A, D, E, and K—and make changes to your diet and lifestyle.

CREON On Course offers several easy and convenient resources to help you.

Find co-pay assistance for CREON® (pancrelipase)

Co-pay assistance*

With the CREON On Course co-pay card, you pay as little as $5 PER MONTH for CREON regardless of prescription cost

Get essential multivitamin products from CREON On Course at no charge


A variety of multivitamin products suited to your individual needs and preferences at no charge

Sign up to receive helpful email reminders from CREON On Course

Helpful refill reminders

Email reminders can let you know when it’s time to refill your CREON prescription

Contact our CREON On Course Support team

Support hotline

Get answers with a simple phone call (844-ONCREON) 1-844-662-7366.

Sign up to receive educational emails for CREON® (pancrelipase)

Educational emails

Get timely updates on savings opportunities, tips for taking CREON, and other subjects that interest you

Signing up for CREON On Course is fast and easy—register today!

Register Now

*Eligibility: Available to patients with commercial prescription insurance coverage for CREON. Co-pay assistance program and multivitamin products are not available to patients receiving prescription reimbursement under any federal, state, or government-funded insurance programs (for example, Medicare, Medicaid, TRICARE, Department of Defense, or Veterans Affairs programs) or where prohibited by law. Offer subject to change or discontinuance without notice. Restrictions, including monthly maximums, may apply. This is not health insurance.

Sign up for friendly reminders and diet tips through CREON® (pancrelipase) support programs

Save money with the CREON co-pay card

Activate Card Now
Learning the basics about CREON® (pancrelipase) is easy

Learning the basics about CREON is easy

Watch Videos
Tracking treatment can help your doctor see if your therapy is working for you

Tracking treatment can help your doctor see if your therapy is working for you

Treatment Tracker

Uses and Important Safety Information


CREON is a prescription medicine used to treat people who cannot digest food normally because their pancreas does not make enough enzymes due to cystic fibrosis, swelling of the pancreas that lasts a long time (chronic pancreatitis), removal of some or all of the pancreas (pancreatectomy), or other conditions.

Important Safety Information

  • CREON may increase your chance of having a rare bowel disorder called fibrosing colonopathy. The risk of having this condition may be reduced by following the dosing instructions that your doctor gave you.
  • Do not crush or chew CREON capsules or its contents, and do not hold the capsule or capsule contents in your mouth. Crushing, chewing, or holding the CREON capsules in your mouth may cause irritation in your mouth. Talk to your doctor or consult the CREON Medication Guide for how to take CREON if you have trouble swallowing capsules. Always take CREON with a meal or snack and enough liquid to swallow CREON completely. Take CREON exactly as your doctor tells you.
  • Tell your doctor right away if you have unusual or severe: stomach (abdominal) pain, bloating, trouble passing stool, nausea, vomiting, diarrhea, worsening of painful, swollen joints (gout), or allergic reactions including trouble with breathing, skin rashes, or swollen lips.
  • The most common side effects include: increased (hyperglycemia) or decreased (hypoglycemia) blood sugars, pain in your stomach area (abdominal area), frequent or abnormal bowel movements, gas, vomiting, dizziness, or sore throat and cough.
  • CREON and other pancreatic enzyme products are made from the pancreas of pigs, the same pigs people eat as pork. These pigs may carry viruses. Although it has never been reported, it may be possible for a person to get a viral infection from taking pancreatic enzyme products that come from pigs.

Refer to the CREON Medication Guide and Full Prescribing Information every time you refill your prescription because information may change. Tell your healthcare provider if you have any symptom or side effect that bothers you or that does not go away.

You are encouraged to report negative adverse effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

If you cannot afford your medication, contact

Reference: 1. CREON [package insert]. North Chicago, IL: AbbVie Inc.

  1. Reference:
  2. CREON [package insert]. North Chicago, IL: AbbVie Inc.

back to top Back to Top Arrow