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What Is CREON?

CREON (pancrelipase) is a prescription medicine used to treat people who cannot digest food normally because their pancreas does not make enough enzymes. This condition is called exocrine pancreatic insufficiency (EPI) and may be due to cystic fibrosis, swelling of the pancreas that lasts a long time (chronic pancreatitis), removal of some or all of the pancreas (pancreatectomy), or other conditions.1

If you have EPI due to one of these conditions, CREON can help break down food into fats, proteins, and carbohydrates1 that your body can use.

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What Is EPI?

Your pancreas normally produces 3 key digestive enzymes that help break down your food into nutrients. If you have a condition known as exocrine pancreatic insufficiency or (EPI), you do not have enough pancreatic enzymes, so your body has trouble breaking down and absorbing the food you eat.2,3


CREON® (pancrelipase) is used to treat people who cannot digest food normally because their pancreas does not make enough enzymes.


CREON® (pancrelipase) replaces pancreatic enzymes such as Protease.


CREON® (pancrelipase) replaces pancreatic enzymes such as Amylase.


CREON® (pancrelipase) replaces pancreatic enzymes such as Lipase.


How to Take CREON

You should take CREON every time you eat—with every meal and snack. You should always take CREON exactly the way your doctor tells you. Your doctor has prescribed your CREON dose specifically for you based on things like your body weight and diet.

Read More About
CREON Dosing

Staying on Track

If you’re taking CREON, make sure you record what you’re eating, how you’re feeling, and when you take your enzymes. When you have a checkup, share this information with your doctor and discuss how your treatment plan is going.

Over time, your doctor may adjust your dose to meet your changing needs.

Get Other Tips and Tools
Support for people with EPI due to chronic pancreatitis, pancreatectomy, or other conditions that are not cystic fibrosis.
Support for people with EPI due to cystic fibrosis (CF)
Find co-pay assistance for CREON®


CREON® offers vitamins and nutritional support to patients with EPI


Sign up for educational support


CREON Treatment Support

Most eligible CREON patients could PAY $5 (or less) per month regardless of prescription cost.4 By enrolling in one of CREON's patient support programs, CREON On Course or CFCareForward, you'll have access to financial savings, multivitamins, and educational resources (certain restrictions apply).*

Learn More About
Support Programs

*Eligibility: Available to patients with commercial prescription insurance coverage for CREON who meet eligibility criteria. Co-pay assistance program is not available to patients receiving prescription reimbursement under any federal, state or government-funded insurance programs (for example, Medicare [including Part D], Medicare Advantage, Medigap, Medicaid, TRICARE, Department of Defense or Veterans Affairs programs) or where prohibited by law or by the patient’s health insurance provider. If at any time a patient begins receiving prescription drug coverage under any such federal, state or government-funded healthcare program, patient will no longer be able to use the Co-Pay card and patient must call 1-855-CARE4WD (227-3493) if enrolled in CFCareForward or 1-844-ONCREON (662-7366) if enrolled in CREON On Course to stop participation. Patients residing in or receiving treatment in certain states may not be eligible. Patients may not seek reimbursement for value received from the CFCareForward or CREON On Course from any third-party payers. Offer subject to change or discontinuance without notice. Restrictions, including monthly maximums, may apply. This is not health insurance. Please see full Terms and Conditions.

Sign Up for Patient Support and More

Interested in signing up for patient support? Want to stay on top of the latest news about CREON and EPI treatment? Interested in sharing your story? Register to receive more information.

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Uses and Important Safety Information


CREON is a prescription medicine used to treat people who cannot digest food normally because their pancreas does not make enough enzymes due to cystic fibrosis, swelling of the pancreas that lasts a long time (chronic pancreatitis), removal of some or all of the pancreas (pancreatectomy), or other conditions.

Important Safety Information

  • CREON may increase your chance of having a rare bowel disorder called fibrosing colonopathy. The risk of having this condition may be reduced by following the dosing instructions that your doctor gave you.
  • Do not crush or chew CREON capsules or its contents, and do not hold the capsule or capsule contents in your mouth. Crushing, chewing, or holding the CREON capsules in your mouth may cause irritation in your mouth. Talk to your doctor or consult the CREON Medication Guide for how to take CREON if you have trouble swallowing capsules. Always take CREON with a meal or snack and enough liquid to swallow CREON completely. Take CREON exactly as your doctor tells you.
  • Tell your doctor right away if you have unusual or severe: stomach (abdominal) pain, bloating, trouble passing stool, nausea, vomiting, diarrhea, worsening of painful, swollen joints (gout), or allergic reactions including trouble with breathing, skin rashes, or swollen lips.
  • The most common side effects include: increased (hyperglycemia) or decreased (hypoglycemia) blood sugars, pain in your stomach area (abdominal area), frequent or abnormal bowel movements, gas, vomiting, dizziness, or sore throat and cough.
  • CREON and other pancreatic enzyme products are made from the pancreas of pigs, the same pigs people eat as pork. These pigs may carry viruses. Although it has never been reported, it may be possible for a person to get a viral infection from taking pancreatic enzyme products that come from pigs.

Refer to the CREON Medication Guide and Full Prescribing Information every time you refill your prescription because information may change. Tell your healthcare provider if you have any symptom or side effect that bothers you or that does not go away.

You are encouraged to report negative adverse effects of prescription drugs to the FDA. Visit or call 1-800-FDA-1088.

If you cannot afford your medication, contact

Reference: 1. CREON [package insert]. North Chicago, IL: AbbVie Inc.

  1. References:
  2. CREON [package insert]. North Chicago, IL: AbbVie Inc.
  3. Ferrone M, Raimondo M, Scolapio JS. Pancreatic enzyme pharmacotherapy. Pharmacotherapy. 2007;27(6):910-920.
  4. Fieker A, Philpott J, Armand M. Enzyme replacement therapy for pancreatic insufficiency: present and future. Clin Exp Gastroenterol. 2011;4:55-73.
  5. Data on file. North Chicago, IL: AbbVie Inc. Source: Amundsen Group, Jan 2012‑June 2016, 2016.

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