How CREON Should Be Given to Infants

Giving CREON to your infant up to 12 months old

CREON may be prescribed to infants who have exocrine pancreatic insufficiency (EPI) due to cystic fibrosis (CF). If you’re caring for an infant who needs to take CREON, you can sprinkle the capsule contents from the CREON capsule either directly in your baby’s mouth or in a small amount of applesauce, which you can feed your baby just before you give him or her breast milk or formula.

Sprinkling instructions:

Hold CREON® (pancrelipase) capsules upright so you can read the word CREON® on the capsule.

Hold the capsule upright so that you can see the word CREON on the capsule.

Carefully twist off the top portion of the capsule to open it.

Carefully twist off the top portion of the capsule.

Sprinkle the beads from the capsule directly into your infant’s mouth, or mix the contents in a small amount of room temperature acidic soft food such as applesauce or jarred baby food.

Sprinkle the contents from the capsule directly into your infant’s mouth, or mix the contents in a small amount of room temperature acidic soft food such as applesauce or jarred baby food. Do not mix CREON with formula or bottled breast milk. If you sprinkle CREON on soft food, feed it to your child immediately. Do not store leftover food mixed with CREON.

Give your child enough liquid to completely swallow the CREON® (pancrelipase) or the CREON and food mixture.

Give your child enough liquid to completely swallow the CREON contents or the CREON and food mixture. Check inside your baby’s mouth that he or she has swallowed all the capsule contents. To avoid irritation, care should be taken to ensure no medicine is left in the mouth. Refer to the CREON Medication Guide for additional instructions.

Capsules shown are not actual size and do not represent actual color shade.

Key points when giving CREON to infants:

Safety Considerations:

CREON may increase your chance of having a rare bowel disorder called fibrosing colonopathy. Call your healthcare professional right away if you have any unusual or severe stomach pain; frequent or abnormal bowel movements; bloating; trouble passing stool; nausea; vomiting; diarrhea; worsening of gout; painful, swollen joints; trouble with breathing; skin rashes; or swollen lips. When taking CREON, it's important to follow the dosing instructions provided by your healthcare professional. Always take CREON with food. Do not crush or chew CREON capsules or the contents of the capsule. This may cause mouth irritation.

Hear from other people who have EPI

Hear from other people who have EPI

Watch Videos
Learning the basics about CREON® (pancrelipase) is easy

Learning the basics about CREON is easy

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CREON® (pancrelipase) can help break down food and release nutrients

CREON can help break down food and release nutrients

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Uses and Important Safety Information

Uses1

CREON is a prescription medicine used to treat people who cannot digest food normally because their pancreas does not make enough enzymes due to cystic fibrosis, swelling of the pancreas that lasts a long time (chronic pancreatitis), removal of some or all of the pancreas (pancreatectomy), or other conditions.

Important Safety Information

  • CREON may increase your chance of having a rare bowel disorder called fibrosing colonopathy. The risk of having this condition may be reduced by following the dosing instructions that your doctor gave you.
  • Do not crush or chew CREON capsules or its contents, and do not hold the capsule or capsule contents in your mouth. Crushing, chewing, or holding the CREON capsules in your mouth may cause irritation in your mouth. Talk to your doctor or consult the CREON Medication Guide for how to take CREON if you have trouble swallowing capsules. Always take CREON with a meal or snack and enough liquid to swallow CREON completely. Take CREON exactly as your doctor tells you.
  • Tell your doctor right away if you have unusual or severe: stomach (abdominal) pain, bloating, trouble passing stool, nausea, vomiting, diarrhea, worsening of painful, swollen joints (gout), or allergic reactions including trouble with breathing, skin rashes, or swollen lips.
  • The most common side effects include: increased (hyperglycemia) or decreased (hypoglycemia) blood sugars, pain in your stomach area (abdominal area), frequent or abnormal bowel movements, gas, vomiting, dizziness, or sore throat and cough.
  • CREON and other pancreatic enzyme products are made from the pancreas of pigs, the same pigs people eat as pork. These pigs may carry viruses. Although it has never been reported, it may be possible for a person to get a viral infection from taking pancreatic enzyme products that come from pigs.

Refer to the CREON Medication Guide and Full Prescribing Information every time you refill your prescription because information may change. Tell your healthcare provider if you have any symptom or side effect that bothers you or that does not go away.

You are encouraged to report negative adverse effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you cannot afford your medication, contact www.pparx.org.

Reference: 1. CREON [package insert]. North Chicago, IL: AbbVie Inc.

  1. Reference:
  2. CREON [package insert]. North Chicago, IL: AbbVie Inc.

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