Understanding CREON Dosing

CREON dosing is based on your specific needs

Your doctor will prescribe your CREON dose specifically for you based on things like your body weight and diet.1 It’s important that you work with your doctor to make sure the dose you’re taking is appropriate for you.

Talking about your GI symptoms with your doctor will help provide the best CREON® (pancrelipase) dose.

Some important things to keep in mind:

Your first dose is a starting point

Your doctor prescribed your CREON dose according to things such as how much you weigh and what you eat. The idea is to start with the lowest dose that may be appropriate and see how it works.1

After you have taken CREON for a couple of weeks, keep track of what you are experiencing and share it with your doctor; your dose may need to be adjusted.

One size doesn’t fit all

Think of it this way: sometimes you have to try on a few pairs of shoes to figure out which ones fit. The same can be said about your dose; your doctor may adjust it depending on how things are going.

Talk about your symptoms with your doctor

Keep track of any gastrointestinal (GI) symptoms you may be experiencing and discuss them with your doctor. Your dose may need to be adjusted.

It’s always a good idea to eat healthy

Doctors recommend a healthy, balanced diet for people with and without EPI. Talk to your doctor about your current diet and consider any recommendations your doctor may have.

Having all the facts can help your doctor prescribe an appropriate CREON dose

Keep your doctor up to date on any symptoms you may still have or any changes to your diet or weight. Use the Treatment Tracker to keep track of any symptoms you experience and talk with your doctor at your next visit.

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CREON can help break down food and release nutrients

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Knowing what foods may cause issues is important

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Uses and Important Safety Information


CREON is a prescription medicine used to treat people who cannot digest food normally because their pancreas does not make enough enzymes due to cystic fibrosis, swelling of the pancreas that lasts a long time (chronic pancreatitis), removal of some or all of the pancreas (pancreatectomy), or other conditions.

Important Safety Information

  • CREON may increase your chance of having a rare bowel disorder called fibrosing colonopathy. The risk of having this condition may be reduced by following the dosing instructions that your doctor gave you.
  • Do not crush or chew CREON capsules or its contents, and do not hold the capsule or capsule contents in your mouth. Crushing, chewing, or holding the CREON capsules in your mouth may cause irritation in your mouth. Talk to your doctor or consult the CREON Medication Guide for how to take CREON if you have trouble swallowing capsules. Always take CREON with a meal or snack and enough liquid to swallow CREON completely. Take CREON exactly as your doctor tells you.
  • Tell your doctor right away if you have unusual or severe: stomach (abdominal) pain, bloating, trouble passing stool, nausea, vomiting, diarrhea, worsening of painful, swollen joints (gout), or allergic reactions including trouble with breathing, skin rashes, or swollen lips.
  • The most common side effects include: increased (hyperglycemia) or decreased (hypoglycemia) blood sugars, pain in your stomach area (abdominal area), frequent or abnormal bowel movements, gas, vomiting, dizziness, or sore throat and cough.
  • CREON and other pancreatic enzyme products are made from the pancreas of pigs, the same pigs people eat as pork. These pigs may carry viruses. Although it has never been reported, it may be possible for a person to get a viral infection from taking pancreatic enzyme products that come from pigs.

Refer to the CREON Medication Guide and Full Prescribing Information every time you refill your prescription because information may change. Tell your healthcare provider if you have any symptom or side effect that bothers you or that does not go away.

You are encouraged to report negative adverse effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you cannot afford your medication, contact www.pparx.org.

Reference: 1. CREON [package insert]. North Chicago, IL: AbbVie Inc.

  1. Reference:
  2. CREON [package insert]. North Chicago, IL: AbbVie Inc.

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