What Is EPI?

Learn about Exocrine Pancreatic Insufficiency (EPI)

EPI is the medical term for a condition that occurs when the pancreas doesn’t
produce enough digestive enzymes. As a result, the body cannot properly digest
food into nutrients, which can lead to malabsorption.2

EPI is a condition
that affects the
pancreas

The pancreas is an organ behind the
stomach that makes 3 types of
enzymes—lipase, protease, and
amylase. These enzymes help the
body digest food into nutrients.3

Pancreatic enzymes:

  • Lipase

    breaks down fats

  • Protease

    breaks down proteins

  • Amylase

    breaks down carbohydrates

EPI is a condition
that affects the
pancreas

The pancreas is an organ behind the
stomach that makes 3 types of
enzymes—lipase, protease, and
amylase. These enzymes help the
body digest food into nutrients.3

Pancreatic enzymes:

  • Lipase

    breaks down fats

  • Protease

    breaks down proteins

  • Amylase

    breaks down carbohydrates

Food isn't digested
properly with EPI

In people with EPI, the pancreas does
not produce enough enzymes to
properly digest food. Fats, in particular,
are hard for people with EPI to break
down. Also, fat-soluble vitamins A, D, E,
and K may not be properly absorbed.2

Consequences of EPI

When there aren’t enough enzymes to
break down food due to EPI, nutrients
may not be properly absorbed by the
intestines. Unabsorbed food in the
intestines can lead to oily, loose,
foul-smelling stools, bloating, gas,
unexplained weight loss, diarrhea, and
stomach pain.2,4,5

Learn More About EPI Symptoms
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Underlying conditions and
procedures that may cause EPI

Learn More
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Your medical history and tests can
help determine if you have EPI

See How