How to Take CREON

CREON should be taken with every meal
and snack

Your pancreas normally produces enzymes every time you eat. CREON should be taken every time you eat to replace the enzymes your pancreas isn't making if you have exocrine pancreatic insufficiency (EPI).2 CREON only works when taken with food.

  • Take CREON® (pancrelipase) with every meal
    Every Meal

    Your doctor will let you know how much CREON
    you need to take during each meal.

  • Take CREON® (pancrelipase) with every snack
    Every Snack

    Usually, half of your prescribed CREON dose
    should be taken with each snack.

  • Take CREON® every day
    Every Day

    It’s important that you take CREON every time
    you eat, every day of the week.

Key points to remember
when taking CREON:

Safety Considerations:

CREON may increase your chance of having a rare bowel disorder called fibrosing colonopathy. Call your healthcare professional right away if you have any unusual or severe stomach pain; frequent or abnormal bowel movements; bloating; trouble passing stool; nausea; vomiting; diarrhea; worsening of gout; painful, swollen joints; trouble with breathing; skin rashes; or swollen lips. When taking CREON, it's important to follow the dosing instructions provided by your healthcare professional. Always take CREON with food. Do not crush or chew CREON capsules or the contents of the capsule. This may cause mouth irritation.

Your doctor will adjust your CREON® (pancrelipase) dose to you and your needs

Your doctor will adjust your CREON dose to you and your needs

Learn About Dosing
Learning the basics about CREON® (pancrelipase) is easy

Learning the basics about CREON is easy

Watch Videos
What can I eat with CREON® (pancrelipase)?

What can I eat with CREON?

Learn About
Diet & Lifestyle

Uses and Important Safety Information

Uses1

CREON is a prescription medicine used to treat people who cannot digest food normally because their pancreas does not make enough enzymes due to cystic fibrosis, swelling of the pancreas that lasts a long time (chronic pancreatitis), removal of some or all of the pancreas (pancreatectomy), or other conditions.

Important Safety Information

  • CREON may increase your chance of having a rare bowel disorder called fibrosing colonopathy. The risk of having this condition may be reduced by following the dosing instructions that your doctor gave you.
  • Do not crush or chew CREON capsules or its contents, and do not hold the capsule or capsule contents in your mouth. Crushing, chewing, or holding the CREON capsules in your mouth may cause irritation in your mouth. Talk to your doctor or consult the CREON Medication Guide for how to take CREON if you have trouble swallowing capsules. Always take CREON with a meal or snack and enough liquid to swallow CREON completely. Take CREON exactly as your doctor tells you.
  • Tell your doctor right away if you have unusual or severe: stomach (abdominal) pain, bloating, trouble passing stool, nausea, vomiting, diarrhea, worsening of painful, swollen joints (gout), or allergic reactions including trouble with breathing, skin rashes, or swollen lips.
  • The most common side effects include: increased (hyperglycemia) or decreased (hypoglycemia) blood sugars, pain in your stomach area (abdominal area), frequent or abnormal bowel movements, gas, vomiting, dizziness, or sore throat and cough.
  • CREON and other pancreatic enzyme products are made from the pancreas of pigs, the same pigs people eat as pork. These pigs may carry viruses. Although it has never been reported, it may be possible for a person to get a viral infection from taking pancreatic enzyme products that come from pigs.

Refer to the CREON Medication Guide and Full Prescribing Information every time you refill your prescription because information may change. Tell your healthcare provider if you have any symptom or side effect that bothers you or that does not go away.

You are encouraged to report negative adverse effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

If you cannot afford your medication, contact www.pparx.org.

Reference: 1. CREON [package insert]. North Chicago, IL: AbbVie Inc.

  1. References:
  2. CREON [package insert]. North Chicago, IL: AbbVie Inc.
  3. Ferrone M, Raimondo M, Scolapio JS. Pancreatic enzyme pharmacotherapy. Pharmacotherapy. 2007;27(6):910-920.

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